Glycogen synthase kinase 3ОІ dictates podocyte motility and focal adhesion turnover by modulating paxillin activity implications for the protective effect of low dose lithium in podocytopathy viagra priligy To investigate these mechanisms, we combined DISC1 truncated transgenic mice, opto chemogenetic manipulations, slice electrophysiology, and behavioral analyses to demonstrate that 1 DISC1 N TM mice have an impairment in risk avoidance, 2 dysfunction of NAc fast spiking PV neurons is responsible for the deficits in risk avoidance, and 3 optogenetic activation of NAc PV neurons rescues the impaired risk avoidance behavior in DISC1 N TM mice
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Glycogen synthase kinase 3ОІ dictates podocyte motility and focal adhesion turnover by modulating paxillin activity implications for the protective effect of low dose lithium in podocytopathy viagra priligy To investigate these mechanisms, we combined DISC1 truncated transgenic mice, opto chemogenetic manipulations, slice electrophysiology, and behavioral analyses to demonstrate that 1 DISC1 N TM mice have an impairment in risk avoidance, 2 dysfunction of NAc fast spiking PV neurons is responsible for the deficits in risk avoidance, and 3 optogenetic activation of NAc PV neurons rescues the impaired risk avoidance behavior in DISC1 N TM mice